[图文]周丛照(中国科技大学生命科学学院副院长)
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周丛照(中国科技大学生命科学学院副院长)


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    周丛照,男,教授,博士生导师,中国科学院“百人计划”入选者,生命科学学院副院长。1987年至1995年就读于中国科技大学生物系并先后获学士和硕士学位。1999年1月至2000年2月作为联合培养博士生在法国巴黎南大学IGM研究所学习,2000年获中国科学技术大学生命科学学院博士学位。2000年9月至2001年1月在法国巴黎南大学遗传学与微生物学研究所作博士后研究;2001年2月至2003年12月在法国科研中心及巴黎南大学结构基因组学实验室作博士后研究。现为中国科技大学生命科学学院教授、博士生导师,合肥微尺度物质科学国家实验室(筹)研究员。在PNAS、EMBO Reports、Nucleic Acids Research、Journal of Biological Chemistry、Structure、Proteins和Biochemistry等杂志发表研究论文四十余篇。曾获得1998年度安徽省自然科学二等奖和2000年中法科技交流协会生物技术奖。2005年当选中国生物化学与分子生物学学会常务理事。
 
    主要研究兴趣:

    1、 氧化应激的蛋白质相互作用网络(973、863和基金委项目)
利用结构生物学、分子生物学和生物化学的方法系统地研究参与酿酒酵母等模式生物氧化应激反应的蛋白质及其相互作用关系,解析其中一些关键蛋白的三维结构,发现和鉴定一些新的多蛋白质复合物,最终重建氧化应激反应的蛋白质信号转导和相互作用网络,从而加深我们对氧化应激导致的衰老和各种疾病的分子机制的理解,为设计相关药物提供理论基础。

    2、 家蚕丝素合成的机理研究(973、863和基金委项目)
以家蚕丝心蛋白基因的有关研究工作为基础,与最近完成的家蚕全基因组序列相结合,对家蚕基因组中与丝质相关的基因及其编码的蛋白质进行系统分析和深入研究,以理解丝心蛋白基因的高效复制和表达以及丝素的分泌和包装的精细调控的分子机制。

    3、蓝藻异形胞分化和毒素合成的结构生物化学(基金委项目)
利用分子遗传学和结构生物化学的手段,对鱼腥藻的异形胞分化的信号转导网络以及铜绿微囊藻的毒素合成途径进行研究,以期理解蓝藻爆发的生物化学基础,服务于蓝藻的利用和水华污染的治理。

    主要论文(#first author, *corresponding author):
    (1) Zhao MX#, Jiang YL#, Xu BY, Chen Y, Zhang CC and Zhou CZ*. Crystal structure of cyanobacterial signal transduction protein PII in complex with PipX. J Mol Biol. 2010; in press
    (2) Zhao MX, Jiang YL, He YX, Chen YF, Teng YB, Chen Y, Zhang CC* and Zhou CZ*. Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate.Proc Natl Acad Sci USA. 2010; 107(28) 12487-92.
    (3) Du Y, He YX, Gaowa S, Zhang X, Chen Y, Zhang SC and Zhou CZ*. Crystal structures of the apo and GDP-bound forms of a cupin-like protein BbDUF985 from Branchiostoma belcheri tsingtauense. Proteins. 2010; 78(12):2714-9.
    (4) Luo M, Jiang YL, Ma XX, Tang YJ, He YX, Yu J, Zhang RG, Chen Y, and Zhou CZ*. Structural and biochemical characterization of yeast monothiol glutaredoxin Grx6. J Mol Biol. 2010; 398(4):614-22.
    (5) Zhang NN, He YX, Li WF, Teng YB, Yu J, Chen Y, Zhou CZ*. Crystal structures of holo and Cu-deficient Cu/Zn-SOD from the silkworm Bombyx mori and the implications in amyotrophic lateral sclerosis.Proteins. 2010; 78(8):1999-2004.
    (6) He YX#, Huang L#, Xue Y#, Fei X, Teng YB, Rubin-Pitel S, Zhao H* and Zhou CZ*. Crystal structure and computational analyses provide insights into the catalytic mechanism of 2,4-diacetylphloroglucinol hydrolase PhlG from Pseudomonas fluorescens.J Biol Chem. 2010; 285(7):4603-11.
    (7) Ma XX, Jiang YL, He YX, Bao R, Chen Y, Zhou CZ*. Structures of yeast glutathione-S-transferase Gtt2 reveal a new catalytic type of GST family.EMBO Reports. 2009; 10(12):1320-26
    (8) Teng YB, Ma XX, He YX, Jiang YL, Du J, Xiang C, Chen Y, Zhou CZ*. Crystal structure of Arabidopsis translation initiation factor eIF-5A2.Proteins. 2009; 77(3):736-40.
    (9) Bao R, Zhou CZ, Jiang C, Lin SX, Chi CW, Chen Y*. The ternary structure of the double-headed arrowhead protease inhibitor API-A complexed with two trypsins reveals a novel reactive site conformation. J Biol Chem. 2009; 284(39):26676-84.
    (10) He YX, Gui L, Liu YZ, Du Y, Zhou Y, Li P*, Zhou CZ*. Crystal structure of Saccharomyces cerevisiae glutamine synthetase Gln1 suggests a nanotube-like supramolecular assembly.Proteins. 2009; 76(1):249-54.
    (11) Huang L#, Sun F#, Liang C, He YX, Bao R, Liu L* and Zhou CZ*. Structural basis for the unique anti-tumor activity of LZ-8 from the fungus Ganoderma lucidium. Proteins. 2009; 75(2):524-7.
    (12) Zhang WJ#, He YX#, Yang Z, Yu J, Chen Y, Zhou CZ*. Crystal structure of glutathione-dependent phospholipid peroxidase Hyr1 from the yeast Saccharomyces cerevisiae.Proteins. 2008; 73(4):1058-62.
    (13) Yu J, Zhang NN, Yin PD, Cui PX and Zhou CZ* Glutathionylation-triggered conformational changes of glutaredoxin Grx1 from the yeast Saccharomyces cerevisiae. Proteins. 2008; 72: 1077-83
    (14) Yu J and Zhou CZ*. Crystal structure of the dimeric Urm1 from the yeast Saccharomyces cerevisiae. Proteins. 2008; 71: 1050-5
    (15) Yu J and Zhou CZ*. Crystal structure of glutathione reductase Glr1 from the yeast Saccharomyces cerevisiae. Proteins. 2007; 68(4):972-9.
    (16) Bao R, Chen Y*, Tang YJ, Janin J and Zhou CZ*. Crystal structure of the yeast cytoplasmic thioredoxin Trx2. Proteins. 2007; 66 (1): 246-9
    (17) Graziani S, Bernauer J, Skouloubris S, Graille M, Zhou CZ, Marchand C, Decottignies P, van Tilbeurgh H, Myllykallio H, Liebl U*. Catalytic mechanism and structure of viral flavin-dependent thymidylate synthase ThyX. J Biol Chem. 2006; 281: 24048-57.
    (18) Sun J, Zhang J, Wu F, Xu C, Li S, Zhao W, Wu Z, Wu J, Zhou CZ* and Shi Y*. Solution structure and metal binding properties of Kti11p from Saccharomyces cerevisiae. Biochemistry. 2005;44: 8801-9.
    (19) Graille M#, Zhou CZ#, Receveur V, Collinet B, Declerck N and van Tilbeurgh H*. Activation of the LicT transcriptional antiterminator by a domain swing/lock mechanism. J Biol Chem. 2005; 280:14780-9.
    (20) Zhou CZ#, Meyer P#, Quevillon-Cheruel S, de La Sierra-Gallay IL, Collinet B, Graille M, Blondeau K, Leulliot N, Sorel I, Poupon A, Janin J and van Tilbeurghet H*. Crystal structure of the YML079w protein from Saccharomyces cerevisiae reveals a new sequence family of the jellyroll fold. Protein Science. 2005; 14:209-15
    (21) Liger D, Graille M, Zhou CZ, Leulliot N, Quevillon-Cheruel S, Blondeau K, Janin J and van Tilbeurgh H*. Crystal structure and functional characterisation of yeast YLR011wp, an NAD(P)H:FMN reductase with NAD(P)H- and FMN-dependent ferric iron reductase activity.J Biol Chem. 2004;279: 34890-7.
    (22) Graille M, Cheruel S, Leulliot N, Zhou CZ, Li de La Sierra Gallay I, Jacquamet L, Ferrer J-L., Poupon A, Janin J and van Tilbeurgh H*. Crystal structure of the YDR533c S. cerevisiae protein, a class II member of the Hsp 31 family. Structure. 2004; 12: 839-47.
    (23) Zhou CZ, de la Sierra-Gallay IL, Quevillon-Cheruel S, Collinet B, Graille M, Blondeau K, Leulliot N, Sorel I, Poupon A, Janin J and van Tilbeurgh H*. Crystal structure of the yeast PX-domain protein Grd19p complexed to phosphatidylinositol-3-phosphate.J Biol Chem. 2003; 278: 50371–6.
    (24) Zhou CZ, Confalonieri F*, Jacquet M, Perasso R, Li ZG and Janin J. Silk fibroin: Structural implications of a remarkable amino acid sequence. Proteins. 2001; 44(2): 119-22.
    (25) Zhou CZ, Confalonieri F*, Medina N, Esnault C, Zivanovic Y, Yang T, Jacquet M, Janin J, Duguet M, Perasso R and Li ZG. Fine organization of Bombyx mori fibroin heavy chain gene.Nucleic Acids Research. 2000; 28(12): 2413-9.

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